The UNAIDS 41st Programme Coordinating Board (PCB) took place in Geneva, Switzerland December 12-14, 2017, under the leadership of Honorable Kwaku Agyemang-Manu, Health Minister of Ghana. This PCB provided for updates on governance and administrative matters, including decisions taken to continue the implementation of recommendations from the Spring 2017 Global Review Panel (GRP) Joint Programme action plan and development of the strategic resource mobilization plan. Many of us in the NGO Delegation openly challenged and encouraged the Joint Programme, Cosponsors and Members States, that doing ‘business as usual’ was not enough. We maintained our position that the UNAIDS we need needs to do things differently, at headquarters and in the field.